CJC-1295 (Without DAC)

Compound Profile

Class

GHRH Analogue Peptide (DAC-conjugated)

Origin

Synthetic analogue of endogenous Growth Hormone-Releasing Hormone (GHRH), modified for extended half-life

Structure

30 amino acids · Modified GHRH(1-29) backbone · Drug Affinity Complex (DAC) via maleimidoproprionic acid–lysine linkage · Molecular weight ~3,647 Da

Purity

99.1%

Format

Lyophilized powder

Lot

NLR-202606

Overview

CJC-1295 (with DAC) is a synthetic peptide analogue of Growth Hormone-Releasing Hormone (GHRH), a 44-amino-acid hypothalamic peptide that stimulates pituitary somatotroph cells in vivo. The CJC-1295 sequence corresponds to GHRH(1-29) with substitutions to improve protease resistance, conjugated to a Drug Affinity Complex (DAC) moiety that covalently binds to serum albumin after reconstitution, prolonging circulating half-life in pharmacokinetic model studies. It is used in research settings to study the GHRH–GH axis signaling dynamics and receptor binding kinetics.

Key Facts

• Analogue of GHRH(1-29) — the biologically active fragment of the 44-amino-acid hypothalamic hormone
• DAC moiety enables covalent binding to serum albumin for extended half-life in PK studies
• Amino acid substitutions at positions 2, 8, 15, and 27 increase resistance to dipeptidyl peptidase IV (DPP-IV)
• Endogenous GHRH is secreted in pulsatile fashion from the arcuate nucleus of the hypothalamus
• Lyophilized; reconstituted with bacteriostatic water for in vitro or animal model studies
• Strictly for in vitro and animal model research — not for human or veterinary use

Published Research