
Incretin Mimetic Analogue (Research Tagged)
NLP-3 (RT)
Synthetic 39-amino acid peptide with binding affinity for GIP, GLP-1, and glucagon receptor subtypes. Lyophilized, research-grade.
Compound Profile
Overview
NLP-3 (RT) is a research-tagged analogue of the glucagon-like peptide family, used in laboratory studies to investigate NLP receptor binding kinetics, signal transduction pathways, and metabolic enzyme activity. The "RT" designation indicates a research tag appended to the peptide for traceability in binding assays. Glucagon-like peptides are incretin hormones naturally produced in the gut; this compound is a synthetic tool for studying those receptor systems in vitro.
Key Facts
- Member of the proglucagon-derived peptide family
- GLP receptors (GLP-1R, GLP-2R) are G-protein coupled receptors expressed in multiple tissues
- Research-tagged variant used for fluorescent or radiometric binding assays
- Natural GLP-1 is produced by intestinal L-cells in response to nutrient ingestion
- Used exclusively in in vitro receptor binding and signal transduction research
- Not approved for any clinical or veterinary application
Certificate of Analysis
Download CoA (PDF)Published Research
GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review
eClinicalMedicine · 2024 · NCBI
Retatrutide — A Game Changer in Obesity Pharmacotherapy
Biomolecules · 2025 · NCBI
Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis
Proceedings (Baylor University Medical Center) · 2025 · NCBI
For laboratory and research use only. This compound is not a drug, food, or cosmetic and is not intended to diagnose, treat, cure, or prevent any disease. Not for human or veterinary use.